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　　在之前的文章中，我讨论了肥胖体外受精(IVF)患者妊娠率显着降低的数据。
　　这是在试图与他们自己的卵子受孕的普通IVF患者中。然而，捐赠者卵子周期呢?

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　　捐卵受者肥胖是否影响活产率?
　　Zarek等人。来自国家卫生研究院最近在2014年10月在夏威夷檀香山举行的美国生殖医学协会第70届年会上发表了这一重要问题。
　　他们提供了2004年至2012年的3,922次共享供体卵周期的数据。他们分析了体重指数(BMI)对供体卵分享周期中活产的影响，其中BMI不同的受体共享同一供体的卵。
　　在3,922个周期中，2,425(63%)受试者的BMI低于25 kg / m2(对照组)，961(24%)，受试者BMI介于25 - 30 kg / m2之间，344(8%) 30-35kg / m2和192(5%)，接受者BMI高于35kg / m2。
　　受体BMI增加与活产率降低相关，并且在调整受者年龄，转移胚胎数量，胚胎期，胚胎等级和存在严重男性因素(0.990,95%CI 0.981-0.998)时，这种关联持续存在。
　　与正常体重受者相比，BMI大于35 kg / m2的受体亚组的活产率进一步受到影响(RR 0.790,95%CI 0.626-0.977)。这意味着这些患者与对照组相比活产率降低了21%。
　　体重指数介于25-30 kg / m2(0.958,95%CI 0.872,1.053)和BMI介于30-35 kg / m2(0.931,95%CI 0.807,1.072)的受体者之间差异不显着。
　　他们的分析表明，BMI大于35 kg / m2的患者子宫容受性降低。在控制潜在的混杂因素后，这些发现仍然存在。
　　他们得出结论，当BMI超过35 kg / m2时，活产出现临床显着21%的降低。他们以及其他一些研究表明，在试图进行供体卵子周期之前，应该建议肥胖的受体减肥。
　　要与一个减肥计划的生育专家合作，使患者每周可以失去3-4磅，而不会感到饥饿或疲倦，请在InVia的四个芝加哥地区的生育科医生之一预约。
　　In a previous blog, I discussed data that showed a significantly reduced pregnancy rate in obese in vitro fertilization (IVF) patients.
　　This was in regular IVF patients attempting to conceive with their own eggs. However, what about donor egg cycles?
　　Does donor egg recipient obesity affect live birth rate?
　　Zarek et al. from the National Institute for Health recently addressed this important question in a presentation at the 70th Annual Meeting of the American Society for Reproductive Medicine in Honolulu, Hawaii, October 2014.
　　They presented data from 3,922 shared donor egg cycles from 2004 - 2012. They analyzed the impact of body mass index (BMI) on live birth in donor egg sharing cycles in which recipients with differing BMI shared eggs from the same donor.
　　Of the 3,922 cycles, 2,425 (63%) had recipients with a BMI below 25 kg/m2 (control group), 961 (24%) with recipient BMI between 25 － 30 kg/m2, 344 (8%) with recipient BMI between 30 － 35 kg/m2 and 192 (5%) with recipient BMI above 35 kg/m2.
　　Increasing recipient BMI was associated with decreased live birth rate, and the association persisted when adjusted for age of recipient, number of embryos transferred, embryo stage, embryo grade and presence of severe male factor (0.990, 95% CI 0.981-0.998).
　　Live birth was further impacted in the subset of recipients with BMI greater than 35 kg/m2, (RR 0.790, 95% CI 0.626- 0.977) compared to normal weight recipients. This means that these patients had a 21% reduction in live birth rate when compared to the control group.
　　Significant differences were not appreciated in recipients with BMI between 25-30 kg/m2 (0.958, 95% CI 0.872, 1.053) and in recipients with BMI between 30-35 kg/m2 (0.931, 95% CI 0.807, 1.072).
　　Their analysis suggested that patients with a BMI greater than 35 kg/m2 had diminished uterine receptivity. These findings persisted after controlling for potential confounders.
　　They conclude that a clinically significant, 21% reduction in live birth was demonstrated when BMI exceeded 35 kg/m2. They - and other studies - suggest that obese recipients should be counseled to lose weight prior to attempting a donor egg cycle.
　　To work with a fertility specialist with a weight loss program that enables patients to lose 3 - 4 lbs weekly without feeling hungry or tired, make an appointment at one of InVia's four Chicago area fertility cinics.